Does HRT have any side effects


Hormone replacement therapy can be associated with increased risks such as breast cancer, ulcers or cancer of the uterus, cardiovascular diseases such as myocardial infarction, stroke, venous thrombosis and pulmonary embolism. Your doctor will discuss these risks with you and weigh them against the expected benefits.

Livial must not be used in:

suspected or existing pregnancy and breastfeeding;

existing or previous breast cancer or if breast cancer is suspected;

existing or suspected estrogen-dependent tumor, such as a tumor of the lining of the uterus;

unexplained genital bleeding that has not been checked by a doctor;

abnormal growth of the lining of the womb (endometrial hyperplasia);

previous or existing circulatory diseases (such as thrombosis or embolism [blood clots]);

existing or previous heart disease such as angina pectoris or heart attack;

existing or previous stroke; existing or previous transient ischemic attack (circulatory disorder in the brain);

previous or existing liver disease, as long as the liver values ​​are increased;

Hypersensitivity / intolerance to tibolone or one of the ingredients (e.g. lactose);

Porphyria (a congenital disease).

In addition to the benefits of hormone replacement therapy (HRT), there are also some risks that should be considered when deciding whether to start or continue such therapy.

Medical check-ups

Before you start hormone replacement therapy, your doctor should take a careful personal and family history (occurrences of your own illnesses and illnesses in the family). Your doctor will examine the breast and / or uterus and perform a thorough general and pelvic exam. This is followed by periodic check-ups, especially of the breast.

During treatment with Livial, you should see your doctor at regular intervals (at least once a year). As part of these check-ups, your doctor will decide whether treatment can be continued in view of the benefits and risks.

Certain diseases can get worse with treatment.

If you suffer from or have suffered from any of the following illnesses or if you have any of the risks mentioned below, you must tell your doctor; he / she will closely monitor you: uterine growths, endometriosis (appearance of the lining of the uterus with pain and bleeding), estrogen-dependent tumors in the family (e.g. if a member of your family has had breast cancer or uterine cancer), high blood pressure, liver dysfunction, diabetes ( Diabetes mellitus), gallstones, migraines or severe headaches, lupus erythematosus (an autoimmune disease of the skin), previous hyperplasia (thickening) of the uterine lining, epilepsy, asthma, otosclerosis (congenital middle ear hearing loss). Let your doctor know if anything changes in your condition while you are taking Livial.

HRT can sometimes cause fluid retention.

Livial is not a contraceptive and therefore does not protect against pregnancy.

Reasons to stop using Livial immediately:

? a sudden increase in blood pressure;

? Occurrence of jaundice (your skin turns yellow);

? Migraines or unusually severe headaches that you have never had.

Tumor diseases

Uterine cancer

Cases of increased uterine cell growth and cancer have been reported while taking Livial. The risk of cancer increases with the duration of treatment.

If you experience vaginal bleeding and spotting, this is usually not a cause for concern, especially if it occurs during the first few months after starting treatment.

Bleeding that occurs after 6 months of treatment or that continues even after Livial therapy is discontinued should be clarified. These may be due to thickening of the lining of the uterus.

Breast cancer

Women who have or have had breast cancer should not use HRT products (which include Livial).

The risk of breast cancer in women who have been using hormone replacement therapy in the form of estrogens, combinations of estrogens and gestagens, and Livial for long years is slightly increased. This increased risk increases with the duration of use and returns to normal after discontinuation of hormone replacement. Women using Livial have a lower risk of breast cancer than women on combination hormone replacement therapy and a comparable risk to women on estrogen-only therapy.

Make sure that you check your breast for changes that you can see or feel, such as pits in the skin, changes in the nipple, or any other lumps.

Carcinoma of the ovaries

Ovarian cancer is extremely rare but serious. Diagnosis is often difficult because there are often no clear signs of the disease.

Some studies suggest that using an estrogen-only drug for more than 5 years is associated with an increased risk of developing cancer of the ovaries. To date, it is not known whether other HRTs increase the risk as well.

Influence on the heart and blood circulation

Heart disease

HRT is not recommended in women who have or have recently had heart disease. If you have ever had heart disease, you should talk to your doctor about the risk / benefit ratio of Livial treatment.

HRT does not help prevent heart disease.

Studies with conjugated estrogens and medoxyprogesterone acetate (a corpus luteum hormone) showed that women are at the highest risk of heart disease in the first year after starting therapy.

If you have chest pain that radiates into your arms or neck, you should see your doctor as soon as possible and stop HRT treatment until he / she has told you to continue. The pain can be a sign of heart disease.


Recent clinical studies with Livial and other HRT supplements have shown an increased risk of stroke. This increased risk was mainly found in older postmenopausal women (aged 60 and over)