What is the biological function of calmodulin
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Calcium (approx2+) is a secondary messenger substance that regulates a large number of processes in all animal cells. In addition, approx2+ to various proteins such as calmodulin, protein kinase C or troponin C. The Ca2+-Calmodulin complex itself acts as a modulator of various enzymes such as phosphodiesterases, phosphorylase kinases, phospholipases, nitric oxide synthases or adenylate cyclases.
By tying approx2+ or the approx2+-Calmodulin complex, the effector proteins experience a change in conformation and thus also in activity, which can lead to diverse processes in the cell. The figure provides an overview of some of the processes that take place in nerve and glial cells by Ca2+ or the approx2+-Calmodulin complex can be regulated or modulated. Some of these processes are involved in signal transmission or processing. For example, Ca initiates2+ the fusion of neurotransmitter vesicles with the presynaptic membrane and leads to exocytosis of the transmitter substance. By the approx2+-dependent change in the state of activity of postsynaptic receptors, synaptic transmission can be modulated The activation of Ca2+-dependentK+Channel reduces the excitability of the cell membrane.
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