What does SRCC

Signet ring cell carcinoma

Synonyms: signet ring cell carcinoma, signet ring carcinoma
English: signet ring cell carcinoma, SRCC

1 definition

Under a Signet ring cell carcinoma one understands a malignant new formation on certain glands. These tumors usually form near the ducts of the glands and are able to produce large amounts of mucus. Signet ring carcinoma belongs to the group of adenocarcinomas because - as mentioned - they originate from glandular tissue.

2 designation

The cells of a signet ring carcinoma constantly produce large amounts of (often very viscous) mucus, which gradually fills the entire cell body and puts the cell membrane under mechanical tension. The cell nucleus is pushed to the edge of the cell by the displacement forces of the secretion formed. When viewed under the microscope, the arrangements of these cells appear like a kind of signet ring, hence the name of the carcinoma.

3 histology

The strongly expanded, ring-like cells are characteristic. The mucus in the cell contents is given a strong red color by the PAS staining.

4 occurrences

Signet ring carcinoma can in principle occur on all glandular tissues of the organism. By far the most common type of cancer occurs in the stomach. Further possible distribution areas of the signet ring carcinoma are all mucous membranes of the respiratory tract, whereby the salivary glands in particular are at risk. The other glandular epithelia of the gastrointestinal tract are also predestined for the occurrence of this carcinoma. In addition, signet ring cancer occurs regularly in the kidney, liver and pancreas.