Are all Jews identifiable by genetic testing?

Family studies on the predisposition to cancer in children

NOTE: This is a research study and not a substitute for clinical genetics testing. Families may never receive results from the study or many results years from the date of their enrollment. If you are interested in clinical testing, please consider consulting a local genetic counselor or other geneticist. If you've had clinical genetic testing and meet the eligibility criteria for this study as shown below, you can enroll regardless of the results of your clinical genetic testing.

DEFINITION OF FAMILY CANCER FOR THIS PROTOCOL:

In this protocol, the definition of "familial cancer" is met when one of the following conditions is met: Gift:

- A person with a history of cancer diagnosed under the age of 26 has at least one first, second or third degree relative with a diagnosed history of cancer under the age of 51; OR

- A person diagnosed with more than one cancer, at least one of which was diagnosed under the age of 26; OR

- A person with a clinical or molecular diagnosis of a known cancer predisposition syndrome; OR

- a person with a congenital cancer diagnosed before the age of 6 months; OR

- A person with a rare childhood cancer or tumor diagnosed before the age of 26

º Except for human papillomavirus-associated cervical cancer and non-melanoma skin cancer occur in adults.

INCLUSION CRITERIA:

- A person who meets this protocol's definition of "familial cancer" as above.

- Biological relatives of an individual who meet the definition of this Protocol for "familial" cancer "who are either affected by cancer or not affected.

EXCLUSION CRITERIA:

- Inability or unwillingness of the research participant or his person authorized representative (LAR) to give written consent after clarification.

- The participant has received an allogeneic bone marrow transplant and has NO pre-transplant germline (unaffected by cancer) DNA available AND not ready to provide a skin sample.